Line of descent, London.

Threesomics

Yes, mitochondrial rescue matters. But not because it gives kids three parents.

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Sailing a close reach, San Francisco Bay. (Image copyright Nathaniel Pearson)

Three small steps toward genomically sensible healthcare

A talk at the Clinical Genome Conference resonated with some folks, who suggested sharing it. Crucially, that crowd included doctors, who have much to both teach and learn…

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The Shock of the New: What we can say about HeLa's novel variants

The Shock of the New: What we can say about HeLa’s novel variants

The newly published HeLa genome offers glimpses of the conscious woman whose life it stole. To downplay that ethically thorny point, the study’s authors point us mainly toward hard-to-interpret novel variants. But they miss ways in which even some of those might already be informative.

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Harmful by any other name: On clinical variant classification

Harmful by any other name: On clinical variant classification

In Phoenix this week, clinical geneticists have gathered at ACMG to catch up on health-relevant genomic findings and tools, and decide how to best put…

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Aftermath of Sandy, Massachusetts

Genodicy: sequencing, in pain but in vain, to understand violence

A journalist asked me last week to comment on reported plans to sequence — and ostensibly interpret — the genome of Adam Lanza, who killed…

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